Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: HARP;HB-GAM;HBBM;HBBN;HBGF-8;HBNF;Heparin-binding brain mitogen;Heparin-binding growth factor 8;OSF;OSF-1;Osf-1;Osf1;Osteoblast-specific factor 1;PTN;Pleiotrophin
Research Areas:
Conjugation:
Target Species: Mouse
Expression Host: Baculovirus-Insect Cells
Application: ELISA
Fusion tag: None
UNIProt ID: P63089
Accession: P63089
Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.
Concentration:
Activity: Immobilized mouse PTN at 10 μg/ml (100 μl/well) can bind rat SDC1-Fc, The EC50 of rat SDC1-Fc is 0.4-1. 1 μg/ml.
Sequence: Met1-Asp168
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile 20 mM Tris, 1M NaCl, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15.3 kDa
ObservedMW: 20 kDa
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein
Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: HARP;HB-GAM;HBBM;HBBN;HBGF-8;HBNF;Heparin-binding brain mitogen;Heparin-binding growth factor 8;OSF;OSF-1;Osf-1;Osf1;Osteoblast-specific factor 1;PTN;Pleiotrophin
Research Areas:
Conjugation:
Target Species: Mouse
Expression Host: Baculovirus-Insect Cells
Application: ELISA
Fusion tag: None
UNIProt ID: P63089
Accession: P63089
Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.
Concentration:
Activity: Immobilized mouse PTN at 10 μg/ml (100 μl/well) can bind rat SDC1-Fc, The EC50 of rat SDC1-Fc is 0.4-1. 1 μg/ml.
Sequence: Met1-Asp168
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile 20 mM Tris, 1M NaCl, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15.3 kDa
ObservedMW: 20 kDa
Original: $10,181,509.16
-70%$10,181,509.16
$3,054,452.75Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: HARP;HB-GAM;HBBM;HBBN;HBGF-8;HBNF;Heparin-binding brain mitogen;Heparin-binding growth factor 8;OSF;OSF-1;Osf-1;Osf1;Osteoblast-specific factor 1;PTN;Pleiotrophin
Research Areas:
Conjugation:
Target Species: Mouse
Expression Host: Baculovirus-Insect Cells
Application: ELISA
Fusion tag: None
UNIProt ID: P63089
Accession: P63089
Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.
Concentration:
Activity: Immobilized mouse PTN at 10 μg/ml (100 μl/well) can bind rat SDC1-Fc, The EC50 of rat SDC1-Fc is 0.4-1. 1 μg/ml.
Sequence: Met1-Asp168
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile 20 mM Tris, 1M NaCl, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15.3 kDa
ObservedMW: 20 kDa
