Recombinant Human SLAM Family Member 5/SLAMF5/CD84(C-6His-Avi) Biotinylated
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: SLAM
Target Synonym: hCD;mCD;SLAM family member;Cell surface antigen MAX;Leukocyte differentiation antigen CD;Signaling lymphocytic activation molecule;SLAMF;Cell surface antigen MAX.3;hCD84;Hly9-beta;Leukocyte differentiation antigen CD84;LY9B;mCD84;Signaling lymphocytic activation molecule 5;SLAM family member 5;SLAMF5;CD84;GR6
Research Areas: immunology;Stem cells
Conjugation: Biotinylated
Target Species: Human
Expression Host: HEK293 Cells
Application:
Fusion tag: C-His-Avi
UNIProt ID: Q9UIB8
Accession: Q9UIB8
Background: SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.
Concentration:
Activity: Not validated for activity
Sequence: Lys22-Arg220
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 24.9 kDa
ObservedMW: 40-50 kDa
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Recombinant Human SLAM Family Member 5/SLAMF5/CD84(C-6His-Avi) Biotinylated
Recombinant Human SLAM Family Member 5/SLAMF5/CD84(C-6His-Avi) Biotinylated
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: SLAM
Target Synonym: hCD;mCD;SLAM family member;Cell surface antigen MAX;Leukocyte differentiation antigen CD;Signaling lymphocytic activation molecule;SLAMF;Cell surface antigen MAX.3;hCD84;Hly9-beta;Leukocyte differentiation antigen CD84;LY9B;mCD84;Signaling lymphocytic activation molecule 5;SLAM family member 5;SLAMF5;CD84;GR6
Research Areas: immunology;Stem cells
Conjugation: Biotinylated
Target Species: Human
Expression Host: HEK293 Cells
Application:
Fusion tag: C-His-Avi
UNIProt ID: Q9UIB8
Accession: Q9UIB8
Background: SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.
Concentration:
Activity: Not validated for activity
Sequence: Lys22-Arg220
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 24.9 kDa
ObservedMW: 40-50 kDa
Original: $737.62
-70%$737.62
$221.29Product Information
Product Information
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Description
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: SLAM
Target Synonym: hCD;mCD;SLAM family member;Cell surface antigen MAX;Leukocyte differentiation antigen CD;Signaling lymphocytic activation molecule;SLAMF;Cell surface antigen MAX.3;hCD84;Hly9-beta;Leukocyte differentiation antigen CD84;LY9B;mCD84;Signaling lymphocytic activation molecule 5;SLAM family member 5;SLAMF5;CD84;GR6
Research Areas: immunology;Stem cells
Conjugation: Biotinylated
Target Species: Human
Expression Host: HEK293 Cells
Application:
Fusion tag: C-His-Avi
UNIProt ID: Q9UIB8
Accession: Q9UIB8
Background: SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-γproduction, and the interactions between T cells and B cells that are required for germinal center formation.
Concentration:
Activity: Not validated for activity
Sequence: Lys22-Arg220
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 24.9 kDa
ObservedMW: 40-50 kDa
