Recombinant Human IL15RA&IL15 Fusion Protein (Fc Tag)
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Cytokines
Abbreviation: IL15RA&IL15 Fusion
Target Synonym: MGC;IL15RA;CD215;alpha;CD215 antigen;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin 15 receptor;interleukin-15 receptor subunit alpha;MGC104179;AA690181;I15RA;IL 15R alpha;Interleukin 15 receptor alpha;Interleukin 15 receptor subunit alpha;sIL-15 receptor subunit alpha;sIL-15RA;sIL-15R-alpha;Soluble interleukin 15 receptor subunit alpha;Soluble interleukin-15 receptor subunit alpha
Research Areas: Signal Transduction;Cell biology;Cancer;immunology;metabolism
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-Fc
UNIProt ID: Q13261;P40933
Accession: Q13261&P40933
Background: IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
Concentration:
Activity: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells.The ED50 for this effect is 5-20 ng/ml.
Sequence: Ile31-Asp96&Asn49-Ser162(Asn120Asp)
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Trehalose, 4% Mannitol, 0.02% Tween 80 (w/v), pH 7.5.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 46.9 kDa
ObservedMW: 50-60 kDa
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Recombinant Human IL15RA&IL15 Fusion Protein (Fc Tag)
Recombinant Human IL15RA&IL15 Fusion Protein (Fc Tag)
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Cytokines
Abbreviation: IL15RA&IL15 Fusion
Target Synonym: MGC;IL15RA;CD215;alpha;CD215 antigen;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin 15 receptor;interleukin-15 receptor subunit alpha;MGC104179;AA690181;I15RA;IL 15R alpha;Interleukin 15 receptor alpha;Interleukin 15 receptor subunit alpha;sIL-15 receptor subunit alpha;sIL-15RA;sIL-15R-alpha;Soluble interleukin 15 receptor subunit alpha;Soluble interleukin-15 receptor subunit alpha
Research Areas: Signal Transduction;Cell biology;Cancer;immunology;metabolism
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-Fc
UNIProt ID: Q13261;P40933
Accession: Q13261&P40933
Background: IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
Concentration:
Activity: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells.The ED50 for this effect is 5-20 ng/ml.
Sequence: Ile31-Asp96&Asn49-Ser162(Asn120Asp)
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Trehalose, 4% Mannitol, 0.02% Tween 80 (w/v), pH 7.5.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 46.9 kDa
ObservedMW: 50-60 kDa
Original: $3,475,958.97
-70%$3,475,958.97
$1,042,787.69Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Cytokines
Abbreviation: IL15RA&IL15 Fusion
Target Synonym: MGC;IL15RA;CD215;alpha;CD215 antigen;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin 15 receptor;interleukin-15 receptor subunit alpha;MGC104179;AA690181;I15RA;IL 15R alpha;Interleukin 15 receptor alpha;Interleukin 15 receptor subunit alpha;sIL-15 receptor subunit alpha;sIL-15RA;sIL-15R-alpha;Soluble interleukin 15 receptor subunit alpha;Soluble interleukin-15 receptor subunit alpha
Research Areas: Signal Transduction;Cell biology;Cancer;immunology;metabolism
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-Fc
UNIProt ID: Q13261;P40933
Accession: Q13261&P40933
Background: IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
Concentration:
Activity: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells.The ED50 for this effect is 5-20 ng/ml.
Sequence: Ile31-Asp96&Asn49-Ser162(Asn120Asp)
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Trehalose, 4% Mannitol, 0.02% Tween 80 (w/v), pH 7.5.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 46.9 kDa
ObservedMW: 50-60 kDa
