Recombinant Human Cyclophilin A Protein
Size: 50μg
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: Cyclophilin A
Target Synonym: CYPA ;Cyclophilin A;Cyclosporin A-binding protein;PPIA;PPIase A;Peptidyl-prolyl cis-trans isomerase A;Rotamase A;SP18
Research Areas: Signal Transduction;immunology;
Conjugation:
Target Species: Human
Expression Host: E.coli
Application:
Fusion tag: None
UNIProt ID: P62937
Accession: P62937
Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
Concentration:
Activity: Not validated for activity
Sequence: Met 1-Glu165
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 18.0 kDa
ObservedMW: 16 kDa
Product Information
Product Information
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Shipping & Returns
Recombinant Human Cyclophilin A Protein
Recombinant Human Cyclophilin A Protein
Size: 50μg
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: Cyclophilin A
Target Synonym: CYPA ;Cyclophilin A;Cyclosporin A-binding protein;PPIA;PPIase A;Peptidyl-prolyl cis-trans isomerase A;Rotamase A;SP18
Research Areas: Signal Transduction;immunology;
Conjugation:
Target Species: Human
Expression Host: E.coli
Application:
Fusion tag: None
UNIProt ID: P62937
Accession: P62937
Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
Concentration:
Activity: Not validated for activity
Sequence: Met 1-Glu165
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 18.0 kDa
ObservedMW: 16 kDa
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
Size: 50μg
Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation: Cyclophilin A
Target Synonym: CYPA ;Cyclophilin A;Cyclosporin A-binding protein;PPIA;PPIase A;Peptidyl-prolyl cis-trans isomerase A;Rotamase A;SP18
Research Areas: Signal Transduction;immunology;
Conjugation:
Target Species: Human
Expression Host: E.coli
Application:
Fusion tag: None
UNIProt ID: P62937
Accession: P62937
Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
Concentration:
Activity: Not validated for activity
Sequence: Met 1-Glu165
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Reconstitution: Not Applicable
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 18.0 kDa
ObservedMW: 16 kDa
