Recombinant Human Claudin-18.2 (CLDN18.2)-Detergent (Active)
Size: 100ug. Other sizes are also available.
Activity: Yes
Research Areas: Signal Transduction
Uniprot ID: P56856-2
Gene Names: CLDN18.2
Alternative Name(s): (CLDN18.2)
Abbreviation: Recombinant Human CLDN18.2 protein-Detergent (Active)
Organism: Homo sapiens (Human)
Source: Mammalian cell
Expression Region: 1-261aa
Protein Length: Full Length of Isoform A2
Tag Info: C-terminal 10xHis-tagged
Target Protein Sequence: MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
MW: 29.1 kDa
Purity: Greater than 80% as determined by SDS-PAGE.
Endotoxin: Not test
Biological_Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.
Form: Liquid
Buffer: 50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Reconstitution: /
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Relevance: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Reference: "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14: 7624-7634(2008)
Function:
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Recombinant Human Claudin-18.2 (CLDN18.2)-Detergent (Active)
Recombinant Human Claudin-18.2 (CLDN18.2)-Detergent (Active)
Size: 100ug. Other sizes are also available.
Activity: Yes
Research Areas: Signal Transduction
Uniprot ID: P56856-2
Gene Names: CLDN18.2
Alternative Name(s): (CLDN18.2)
Abbreviation: Recombinant Human CLDN18.2 protein-Detergent (Active)
Organism: Homo sapiens (Human)
Source: Mammalian cell
Expression Region: 1-261aa
Protein Length: Full Length of Isoform A2
Tag Info: C-terminal 10xHis-tagged
Target Protein Sequence: MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
MW: 29.1 kDa
Purity: Greater than 80% as determined by SDS-PAGE.
Endotoxin: Not test
Biological_Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.
Form: Liquid
Buffer: 50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Reconstitution: /
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Relevance: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Reference: "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14: 7624-7634(2008)
Function:
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$355.41Product Information
Product Information
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Description
Size: 100ug. Other sizes are also available.
Activity: Yes
Research Areas: Signal Transduction
Uniprot ID: P56856-2
Gene Names: CLDN18.2
Alternative Name(s): (CLDN18.2)
Abbreviation: Recombinant Human CLDN18.2 protein-Detergent (Active)
Organism: Homo sapiens (Human)
Source: Mammalian cell
Expression Region: 1-261aa
Protein Length: Full Length of Isoform A2
Tag Info: C-terminal 10xHis-tagged
Target Protein Sequence: MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
MW: 29.1 kDa
Purity: Greater than 80% as determined by SDS-PAGE.
Endotoxin: Not test
Biological_Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.
Form: Liquid
Buffer: 50 mM HEPES, 0.15 M NaCl, 0.05% DDM, 0.01% CHS, pH7.5
Reconstitution: /
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Relevance: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Reference: "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14: 7624-7634(2008)
Function:
