Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Immune Checkpoint Proteins
Abbreviation: CD86;B7-2
Target Synonym: LAB;ETC;FUN;CTLA-4 Counter-Receptor B;Early T-cell costimulatory molecule;CD28LG;B7-2;B7.2;B70;CD28LG2;LAB72;CD86;Activation B7-2 antigen;BU63;CTLA-4 Counter-Receptor B7.2;Early T-cell costimulatory molecule 1;ETC-1;FUN-1;T-lymphocyte activation antigen CD86; B7-2;Activation B7-2 antigen 3;B7 2;B72 antigen;B-lymphocyte activation antigen B7-2;B-lymphocyte activation antigen B7-2 2;CD28 antigen ligand 2;CD28 antigen ligand 2 2;Cd28l2;CD86 antigen;CD86 molecule;CLS1;CTLA-4 counter-receptor B7.2 2;FUN 1;Ly58;Ly-58;MB7;MB7-2;Membrane glycoprotein;MGC34413;TS/A-2
Research Areas: Microbiology;immunology;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: BLI
Fusion tag: C-His
UNIProt ID: P42081
Accession: AAH40261.1
Background: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
Concentration:
Activity: Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay.
Sequence: Ala24-Pro247
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 26.7 kDa
ObservedMW: 57-66 kDa
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Product Information
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Shipping & Returns
Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)
Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Immune Checkpoint Proteins
Abbreviation: CD86;B7-2
Target Synonym: LAB;ETC;FUN;CTLA-4 Counter-Receptor B;Early T-cell costimulatory molecule;CD28LG;B7-2;B7.2;B70;CD28LG2;LAB72;CD86;Activation B7-2 antigen;BU63;CTLA-4 Counter-Receptor B7.2;Early T-cell costimulatory molecule 1;ETC-1;FUN-1;T-lymphocyte activation antigen CD86; B7-2;Activation B7-2 antigen 3;B7 2;B72 antigen;B-lymphocyte activation antigen B7-2;B-lymphocyte activation antigen B7-2 2;CD28 antigen ligand 2;CD28 antigen ligand 2 2;Cd28l2;CD86 antigen;CD86 molecule;CLS1;CTLA-4 counter-receptor B7.2 2;FUN 1;Ly58;Ly-58;MB7;MB7-2;Membrane glycoprotein;MGC34413;TS/A-2
Research Areas: Microbiology;immunology;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: BLI
Fusion tag: C-His
UNIProt ID: P42081
Accession: AAH40261.1
Background: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
Concentration:
Activity: Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay.
Sequence: Ala24-Pro247
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 26.7 kDa
ObservedMW: 57-66 kDa
Original: $2,247,018.71
-70%$2,247,018.71
$674,105.61Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
Size: 50μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Immune Checkpoint Proteins
Abbreviation: CD86;B7-2
Target Synonym: LAB;ETC;FUN;CTLA-4 Counter-Receptor B;Early T-cell costimulatory molecule;CD28LG;B7-2;B7.2;B70;CD28LG2;LAB72;CD86;Activation B7-2 antigen;BU63;CTLA-4 Counter-Receptor B7.2;Early T-cell costimulatory molecule 1;ETC-1;FUN-1;T-lymphocyte activation antigen CD86; B7-2;Activation B7-2 antigen 3;B7 2;B72 antigen;B-lymphocyte activation antigen B7-2;B-lymphocyte activation antigen B7-2 2;CD28 antigen ligand 2;CD28 antigen ligand 2 2;Cd28l2;CD86 antigen;CD86 molecule;CLS1;CTLA-4 counter-receptor B7.2 2;FUN 1;Ly58;Ly-58;MB7;MB7-2;Membrane glycoprotein;MGC34413;TS/A-2
Research Areas: Microbiology;immunology;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: BLI
Fusion tag: C-His
UNIProt ID: P42081
Accession: AAH40261.1
Background: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.
Concentration:
Activity: Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay.
Sequence: Ala24-Pro247
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 26.7 kDa
ObservedMW: 57-66 kDa
