Recombinant Human ALK-2/ACVR1 Protein (His & Fc Tag)
Size: 200μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-I;ACVR1;ACVR1A;ACVRLK2;ALK-2;ALK2;Activin Receptor Type I;Activin Receptor Type-1;Activin Receptor-Like Kinase 2;FOP;SKR1;Serine/Threonine-Protein Kinase Receptor R1;TGF-B Superfamily Receptor Type I;TSR-I
Research Areas: Signal Transduction;epigenetics and nuclear signal;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: ELISA
Fusion tag: C-His-Fc
UNIProt ID: Q04771
Accession: NP_001104537.1
Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
Concentration:
Activity: Measure by its ability to bind with human BMP2 in a functional ELISA.
Sequence: Met 1-Val 124
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 39.6 kDa
ObservedMW: 40-45 kDa
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Recombinant Human ALK-2/ACVR1 Protein (His & Fc Tag)
Recombinant Human ALK-2/ACVR1 Protein (His & Fc Tag)
Size: 200μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-I;ACVR1;ACVR1A;ACVRLK2;ALK-2;ALK2;Activin Receptor Type I;Activin Receptor Type-1;Activin Receptor-Like Kinase 2;FOP;SKR1;Serine/Threonine-Protein Kinase Receptor R1;TGF-B Superfamily Receptor Type I;TSR-I
Research Areas: Signal Transduction;epigenetics and nuclear signal;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: ELISA
Fusion tag: C-His-Fc
UNIProt ID: Q04771
Accession: NP_001104537.1
Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
Concentration:
Activity: Measure by its ability to bind with human BMP2 in a functional ELISA.
Sequence: Met 1-Val 124
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 39.6 kDa
ObservedMW: 40-45 kDa
Original: $18,256,574.14
-70%$18,256,574.14
$5,476,972.24Product Information
Product Information
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Description
Size: 200μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-I;ACVR1;ACVR1A;ACVRLK2;ALK-2;ALK2;Activin Receptor Type I;Activin Receptor Type-1;Activin Receptor-Like Kinase 2;FOP;SKR1;Serine/Threonine-Protein Kinase Receptor R1;TGF-B Superfamily Receptor Type I;TSR-I
Research Areas: Signal Transduction;epigenetics and nuclear signal;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: ELISA
Fusion tag: C-His-Fc
UNIProt ID: Q04771
Accession: NP_001104537.1
Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
Concentration:
Activity: Measure by its ability to bind with human BMP2 in a functional ELISA.
Sequence: Met 1-Val 124
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 39.6 kDa
ObservedMW: 40-45 kDa
