Recombinant Human ACVR2B/ActivinR-IIB Protein (His Tag)
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-IIB;ACVR2B;Activin Receptor Type IIB;Activin Receptor Type-2B;BMP Type II Receptor;BMP Type-2 Receptor;BMPR-4;Bone Morphogenetic Protein Receptor Type II;Bone Morphogenetic Protein Receptor Type-2
Research Areas: Signal Transduction;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-His
UNIProt ID: Q13705
Accession: NP_001097.2
Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Concentration:
Activity: 1. Measured by its ability to bind biotinylated Human INHBA-his and Mouse INHBA-his in functional ELISA. 2. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 µg/mL in the presence of 10 ng/mL recombinant Activin A.
Sequence: Met 1-Thr 134
Purity: > 97 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15 kDa
ObservedMW: 33-38 kDa
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Product Information
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Shipping & Returns
Recombinant Human ACVR2B/ActivinR-IIB Protein (His Tag)
Recombinant Human ACVR2B/ActivinR-IIB Protein (His Tag)
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-IIB;ACVR2B;Activin Receptor Type IIB;Activin Receptor Type-2B;BMP Type II Receptor;BMP Type-2 Receptor;BMPR-4;Bone Morphogenetic Protein Receptor Type II;Bone Morphogenetic Protein Receptor Type-2
Research Areas: Signal Transduction;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-His
UNIProt ID: Q13705
Accession: NP_001097.2
Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Concentration:
Activity: 1. Measured by its ability to bind biotinylated Human INHBA-his and Mouse INHBA-his in functional ELISA. 2. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 µg/mL in the presence of 10 ng/mL recombinant Activin A.
Sequence: Met 1-Thr 134
Purity: > 97 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15 kDa
ObservedMW: 33-38 kDa
Original: $5,758,483.62
-70%$5,758,483.62
$1,727,545.09Product Information
Product Information
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Description
Size: 100μg
Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Exp date: 12 months
Category ID_II: Recombinant Proteins
Category ID_III: Others
Abbreviation:
Target Synonym: ACTR-IIB;ACVR2B;Activin Receptor Type IIB;Activin Receptor Type-2B;BMP Type II Receptor;BMP Type-2 Receptor;BMPR-4;Bone Morphogenetic Protein Receptor Type II;Bone Morphogenetic Protein Receptor Type-2
Research Areas: Signal Transduction;Stem cells
Conjugation:
Target Species: Human
Expression Host: HEK293 Cells
Application: Cell culture
Fusion tag: C-His
UNIProt ID: Q13705
Accession: NP_001097.2
Background: ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
Concentration:
Activity: 1. Measured by its ability to bind biotinylated Human INHBA-his and Mouse INHBA-his in functional ELISA. 2. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.3-2 µg/mL in the presence of 10 ng/mL recombinant Activin A.
Sequence: Met 1-Thr 134
Purity: > 97 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: Please refer to the printed manual for detailed information.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Calculated MW: 15 kDa
ObservedMW: 33-38 kDa
