p53RFP Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: RNF144B
Target Synonym: bA528A10.3;E3 ubiquitin protein ligase RNF144B;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain containing protein 2;IBR domain-containing protein 2;IBRDC 2;IBRDC2;KIAA0161;MGC71786;OTTHUMP00000016079;OTTHUMP00000016080;OTTHUMP00000039360;p53 inducible RING finger protein;p53-inducible RING finger protein;p53RFP;PIR2;R144B;Ring finger 144B;RING finger protein 144B;RNF 144B;RNF144B
Research Areas: Cell Biology
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human;Mouse
Application: WB;IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q7Z419
Accession:
Background: p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
Concentration: 0.4 mg/mL
Immunogen: Recombinant protein of human RNF144B
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: WB 1:200-1:1000;IHC 1:50-1:200
Calculated MW: 34kDa
ObservedMW:
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p53RFP Polyclonal Antibody
p53RFP Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: RNF144B
Target Synonym: bA528A10.3;E3 ubiquitin protein ligase RNF144B;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain containing protein 2;IBR domain-containing protein 2;IBRDC 2;IBRDC2;KIAA0161;MGC71786;OTTHUMP00000016079;OTTHUMP00000016080;OTTHUMP00000039360;p53 inducible RING finger protein;p53-inducible RING finger protein;p53RFP;PIR2;R144B;Ring finger 144B;RING finger protein 144B;RNF 144B;RNF144B
Research Areas: Cell Biology
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human;Mouse
Application: WB;IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q7Z419
Accession:
Background: p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
Concentration: 0.4 mg/mL
Immunogen: Recombinant protein of human RNF144B
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: WB 1:200-1:1000;IHC 1:50-1:200
Calculated MW: 34kDa
ObservedMW:
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Description
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: RNF144B
Target Synonym: bA528A10.3;E3 ubiquitin protein ligase RNF144B;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain containing protein 2;IBR domain-containing protein 2;IBRDC 2;IBRDC2;KIAA0161;MGC71786;OTTHUMP00000016079;OTTHUMP00000016080;OTTHUMP00000039360;p53 inducible RING finger protein;p53-inducible RING finger protein;p53RFP;PIR2;R144B;Ring finger 144B;RING finger protein 144B;RNF 144B;RNF144B
Research Areas: Cell Biology
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human;Mouse
Application: WB;IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q7Z419
Accession:
Background: p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
Concentration: 0.4 mg/mL
Immunogen: Recombinant protein of human RNF144B
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: WB 1:200-1:1000;IHC 1:50-1:200
Calculated MW: 34kDa
ObservedMW:
