LCN2 Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: LCN2
Target Synonym: 24p3;25 kDa alpha 2 microglobulin related subunit of MMP9;25 kDa alpha-2-microglobulin-related subunit of MMP-9;Alpha 2 microglobulin related protein;HGNC:6526;HNL;Lcn 2;Lcn2;Lipocalin-2;Migration stimulating factor inhibitor;MSFI;Neutrophil gelatinase associated lipocalin;Neutrophil gelatinase associated lipocalin precursor;Neutrophil gelatinase-associated lipocalin;NGAL;NGAL;Oncogene 24p3;Oncogenic lipocalin 24p3;p25;Siderocalin;siderocalin LCN2;SV40 induced 24P3 protein;Uterocalin
Research Areas: Cancer;Cardiovascular;Metabolism;Immunology;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: P80188
Accession:
Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Concentration: 0.5 mg/mL
Immunogen: Synthetic peptide of human LCN2
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: IHC 1:25-1:100
Calculated MW:
ObservedMW:
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LCN2 Polyclonal Antibody
LCN2 Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: LCN2
Target Synonym: 24p3;25 kDa alpha 2 microglobulin related subunit of MMP9;25 kDa alpha-2-microglobulin-related subunit of MMP-9;Alpha 2 microglobulin related protein;HGNC:6526;HNL;Lcn 2;Lcn2;Lipocalin-2;Migration stimulating factor inhibitor;MSFI;Neutrophil gelatinase associated lipocalin;Neutrophil gelatinase associated lipocalin precursor;Neutrophil gelatinase-associated lipocalin;NGAL;NGAL;Oncogene 24p3;Oncogenic lipocalin 24p3;p25;Siderocalin;siderocalin LCN2;SV40 induced 24P3 protein;Uterocalin
Research Areas: Cancer;Cardiovascular;Metabolism;Immunology;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: P80188
Accession:
Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Concentration: 0.5 mg/mL
Immunogen: Synthetic peptide of human LCN2
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: IHC 1:25-1:100
Calculated MW:
ObservedMW:
Product Information
Product Information
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Description
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: LCN2
Target Synonym: 24p3;25 kDa alpha 2 microglobulin related subunit of MMP9;25 kDa alpha-2-microglobulin-related subunit of MMP-9;Alpha 2 microglobulin related protein;HGNC:6526;HNL;Lcn 2;Lcn2;Lipocalin-2;Migration stimulating factor inhibitor;MSFI;Neutrophil gelatinase associated lipocalin;Neutrophil gelatinase associated lipocalin precursor;Neutrophil gelatinase-associated lipocalin;NGAL;NGAL;Oncogene 24p3;Oncogenic lipocalin 24p3;p25;Siderocalin;siderocalin LCN2;SV40 induced 24P3 protein;Uterocalin
Research Areas: Cancer;Cardiovascular;Metabolism;Immunology;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: P80188
Accession:
Background: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Concentration: 0.5 mg/mL
Immunogen: Synthetic peptide of human LCN2
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Dilution: IHC 1:25-1:100
Calculated MW:
ObservedMW:
