Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: ARIH2

Target Synonym: HT005;all trans retinoic acid inducible RING finger;Ari 2;Ari-2;ARI2;ARI2;Ariadne 2;Ariadne 2 protein homolog;ariadne homolog 2 (Drosophila);ariadne homolog 2;Ariadne RBR E3 ubiquitin protein ligase 2;ARIH 2;Arih2;E3 ubiquitin protein ligase ARIH2;E3 ubiquitin-protein ligase ARIH2;protein ariadne 2 homolog;Protein ariadne-2 homolog;Triad 1;TRIAD1;Triad1 protein;UIP48

Research Areas: Cell Biology;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: O95376

Accession:

Background: TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Concentration: 1.38 mg/mL

Immunogen: Fusion protein of human ARIH2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: WB 1:1000-1:5000;IHC 1:50-1:300

Calculated MW: 58 kDa

ObservedMW: Refer to figures