ACER1 Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: ACER1
Target Synonym: Acer1;ACER1;Acylsphingosine deacylase 3;Alkaline CDase 1;Alkaline ceramidase 1;Alkaline ceramidase;AlkCDase 1;ALKCDase1;ASAH 3;MGC138327;MGC138329;N acylsphingosine amidohydrolase (alkaline ceramidase) 3;N acylsphingosine amidohydrolase 3 alkaline ceramidase;N acylsphingosine amidohydrolase 3;N-acylsphingosine amidohydrolase 3
Research Areas: Cancer;Metabolism;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q8TDN7
Accession:
Background: ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
Concentration: 1.2 mg/mL
Immunogen: Synthetic peptide of human ACER1
Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification method: Antigen affinity purification
Dilution: IHC 1:40-1:200
Calculated MW:
ObservedMW:
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ACER1 Polyclonal Antibody
ACER1 Polyclonal Antibody
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: ACER1
Target Synonym: Acer1;ACER1;Acylsphingosine deacylase 3;Alkaline CDase 1;Alkaline ceramidase 1;Alkaline ceramidase;AlkCDase 1;ALKCDase1;ASAH 3;MGC138327;MGC138329;N acylsphingosine amidohydrolase (alkaline ceramidase) 3;N acylsphingosine amidohydrolase 3 alkaline ceramidase;N acylsphingosine amidohydrolase 3;N-acylsphingosine amidohydrolase 3
Research Areas: Cancer;Metabolism;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q8TDN7
Accession:
Background: ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
Concentration: 1.2 mg/mL
Immunogen: Synthetic peptide of human ACER1
Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification method: Antigen affinity purification
Dilution: IHC 1:40-1:200
Calculated MW:
ObservedMW:
Product Information
Product Information
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Description
Size: 200μL
Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Exp date: 12 months
Category ID_II: Primary Antibodies
Category ID_III: Polyclonal Antibodies
Abbreviation: ACER1
Target Synonym: Acer1;ACER1;Acylsphingosine deacylase 3;Alkaline CDase 1;Alkaline ceramidase 1;Alkaline ceramidase;AlkCDase 1;ALKCDase1;ASAH 3;MGC138327;MGC138329;N acylsphingosine amidohydrolase (alkaline ceramidase) 3;N acylsphingosine amidohydrolase 3 alkaline ceramidase;N acylsphingosine amidohydrolase 3;N-acylsphingosine amidohydrolase 3
Research Areas: Cancer;Metabolism;Signal Transduction
Conjugation: Unconjugated
Host: Rabbit
Species reactivity: Human
Application: IHC
Isotype: IgG
Clonality: Polyclonal
Clone NO.:
UNIProt ID: Q8TDN7
Accession:
Background: ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
Concentration: 1.2 mg/mL
Immunogen: Synthetic peptide of human ACER1
Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification method: Antigen affinity purification
Dilution: IHC 1:40-1:200
Calculated MW:
ObservedMW:
